Centrosome Duplication: Suspending a License by Phosphorylating a Template
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چکیده
منابع مشابه
Centrosome Duplication: Suspending a License by Phosphorylating a Template
The phosphorylation status of Sfi1, a structural component of the yeast centrosome, governs the centrosome duplication cycle, raising the possibility that licensing of centrosome duplication occurs by modulating Sfi1, which potentially acts as a template for a new centrosome.
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Human NDR kinases are upregulated in some cancer types, yet their functions still remain undefined. Here, we report the first known function of a mammalian NDR kinase by demonstrating that human NDR directly contributes to centrosome duplication. A subpopulation of endogenous NDR localizes to centrosomes in a cell-cycle-dependent manner. Overexpression of NDR resulted in centrosome overduplicat...
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been stripped of most of their proteins, the pericentriolar material can be seen to consist of a fibrous core, to which other proteins and complexes are attached. Mi-crotubule nucleation is accomplished by the ␥-tubulin Stanford, California 94305 complex, a large ring-shaped multiprotein complex that localizes to the pericentriolar material and provides a template for the addition of tubulin su...
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Despite over one hundred years of research, the duplication of the centrosome is a poorly understood process. Three recent papers--exploring three different kinases--may have provided the answer.
متن کاملGeminin is partially localized to the centrosome and plays a role in proper centrosome duplication
BACKGROUND INFORMATION Centrosome duplication normally parallels with DNA replication and is responsible for correct segregation of replicated DNA into the daughter cells. Although geminin interacts with Cdt1 to prevent loading of MCMs (minichromosome maintenance proteins) on to the replication origins, inactivation of geminin nevertheless causes centrosome over-duplication in addition to the r...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2014
ISSN: 0960-9822
DOI: 10.1016/j.cub.2014.06.008